Some common heterocyclic compound, 496-15-1, name is Indoline, molecular formula is C8H9N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 496-15-1
COMPARATIVE EXAMPLE 1 1,3-Dihydro-1,3,3-trimethyl-6′-(2,3-dihydroindol-1-yl) spiro[2H-indole-2,3′-3H-naphtho[2,1-b][1,4]oxazine] A mixture of 1-nitroso-2-naphthol (17.3 g; 0.10 mol) and indoline (23.8 g; 0.20 mol) in trichloroethylene (150 ml) was heated under reflux for 10 min. A solution of 1,3-dihydro-1,3,3-trimethyl-2-methyleneindoline (17.3 g; 0.1 mol) in trichloroethylene (100 ml) was added in one batch and the resulting mixture heated under reflux for 1 h. The solution was evaporatedand the oily residue treated with acetone to yield 1,3-Dihydro-1,3,3-trimethyl-6′-(2,3-dihydroindol-1-yl)spiro [2H-indole-2,3′-3H-naphtho[2,1-b][1,4]oxazine] as a yellow solid (4.44 g; 10%). m.p 255-7 C. STR10
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 496-15-1, its application will become more common.
Reference:
Patent; Pilkington plc; US5446151; (1995); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem