Adding a certain compound to certain chemical reactions, such as: 675109-26-9, name is 6-Bromoisoindolin-1-one, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 675109-26-9, Quality Control of 6-Bromoisoindolin-1-one
A mixture of 6-bromoisoindolin-i-one (5 g, 23.6 mmol), sodium azide (3.07 g, 47.2 mmol), sodium ascorbate (234 mg, 1.18 mmol), Cul (450 mg, 2.36 mmol) and trans-N,N-dimethyl- 1 ,2-diaminocyclohexane (504 mg, 3.54 mmol) in ethanol (35 mE) and water (15 mE) was stirred at reflux for 5.5 h under nitrogen. The reaction mixture was allowed to cool to room temperature and extracted with EtOAc (100 mEx3). The combined organic fractions were washed with brine and dried with anhydrous sodium sulfate.The solvent was evaporated under reduced pressure and the residue was purified by chromatography on silica gel (10- 50% EtOAc in pet. ether) to give iSA (1.2 g, 29% yield) as an off-white solid. ESI mlz 175.0 [M+i].
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 6-Bromoisoindolin-1-one, and friends who are interested can also refer to it.
Reference:
Patent; Seal Rock Therapeutics, Inc.; BROWN, Samuel David; US2018/291002; (2018); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem