Synthetic Route of 3485-84-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3485-84-5, name is N-Vinylphthalimide, This compound has unique chemical properties. The synthetic route is as follows.
A mixture consisting of N-vinylphthalimide (2.0 g, 11.5 mmol), vinyltrimethylsilane (2.03 mL, 13.8 mmol), RuHCl(CO)(PCy3)2 (0.167 g, 0.23 mmol), and 23 mL of dry toluene was placed under an argon atmosphere in a 150 mL Schlenk bomb flask fitted with a plug valve and heated at 100 C for 24 h to complete the reaction (GC analysis). Next, after cooling the reaction mixture to room temperature, 92 mL of acetonitrile and N-iodosuccinimide (5.18 g, 23.0 mmol) were added and the mixture was stirred for 24 h at room temperature. After this time the solvents were evaporated and the reaction mixture was quenched with aqueous Na2S2O3, extracted with hexane, and concentrated to dryness. The final product was purified by column chromatography on silica gel, eluting with n-hexane/EtOAc (50/2).
The chemical industry reduces the impact on the environment during synthesis N-Vinylphthalimide. I believe this compound will play a more active role in future production and life.
Reference:
Article; Pawlu?, Piotr; Franczyk, Adrian; Walkowiak, J?drzej; Hreczycho, Grzegorz; Kubicki, MacIej; Marciniec, Bogdan; Tetrahedron; vol. 68; 18; (2012); p. 3545 – 3551;,
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