32692-19-6, name is 5-Nitroindoline, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 32692-19-6
To a stirred solution of chlorosulfonyl isocyanate ( 3.67 g , 26 mmol) in DCM ( 5 ml ), t- butanol (2.07g , 28 mmol) was added dropwise at 0 C under nitrogen atmosphere and stirred for 15 min. This mixture was added to a solution of 5-Nitroindoline (3.7 g, 22 mmol) and TEA ( 6.66 g , 66 mmol) in DCM ( 50 ml ) at 0 C under nitrogen atmosphere and stirred at rt for 8 hr . Solvent was evaporated , water (30 ml ) was added to the residue & the yellow solid was filtered and dried (7.53 g , 90.24%). MS = m/z 343 [M-I].
The synthetic route of 32692-19-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LUPIN LIMITED; WO2009/109999; (2009); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem