Adding a certain compound to certain chemical reactions, such as: 317-20-4, name is 7-Fluoroisatin, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 317-20-4, name: 7-Fluoroisatin
Description 17: 8-Fluoro-3-methyl-2-phenylquinoline-4-carboxylic Acid KOH (88 g, 1560 mmol) in water (400 mL) was added over 30 min. to a suspension of 7-fluoroisatin (64.4 g, 390 mmol) in ethanol (200 mL). Propiophenone (51.9 mL, 390 mmol) was added and the mixture was heated under reflux for 24 h. The mixture was cooled, and hydrochloric acid (conc., 128 mL, 1404 mmol) then acetic acid (11.16 mL, 195 mmol) were added. The mixture was stirred at RT for 16 h. and the solid was collected, washing with water (600 mL), ethanol (200 mL) and hexane/Et2O (1:1, 400 mL). The solid was flushed with toluene (3*500 mL) and dried in vacuo to give the title compound as an off-white solid (91.44 g, 325 mmol, 83%). 1H NMR (500 MHz, DMSO-d6) delta 14.4 (1H, br s), 7.70-7.45 (8H, m), 2.40 (3H, s)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-Fluoroisatin, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Carling, William Robert; Elliott, Jason Matthew; Mezzogori, Elena; Russell, Michael Geoffrey Neil; Williams, Brian John; US2009/54440; (2009); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem