These common heterocyclic compound, 3335-98-6, name is 1-Phenyloxindole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 3335-98-6
General procedure: The mixture of 2,4-dien-1-one (0.5 mmol), indolin-2-one (0.5 mmol, 66.5 mg) and cesium carbonate (0.25 mmol, 81.3 mg) in 3 mL of methylene chloride was stirred at room temperature for 40 min. After the completion monitored by TLC, the solid was filtered, and the liquor was concentrated under reduced pressure. The residue was isolated by column chromatography using petroleum ether and ethyl acetate (v/v 3:1) as eluent to give the pure product. The analytical data for products are given in Tables 1 and 2.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3335-98-6.
Reference:
Article; Song, Geyang; Li, Zheng; Chemical Papers; vol. 72; 6; (2018); p. 1379 – 1388;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem