Introduction of a new synthetic route about 106976-23-2

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 106976-23-2, name is 5-Bromo-6-methylindoline-2,3-dione, A new synthetic method of this compound is introduced below., Recommanded Product: 106976-23-2

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 106976-23-2, name is 5-Bromo-6-methylindoline-2,3-dione, A new synthetic method of this compound is introduced below., Recommanded Product: 106976-23-2

A 30% hydrogen peroxide sol. (2 mL/g) was added to a sol. of isatin derivative in 10 M of sodium hydroxide sol. (10 mL/g) at 70 C. and the reaction mixture was then held at this temperature for 1 h. The mixture was then cooled to 0 C., adjusted to pH 8 with conc. HCl, diluted with EE and then brought to pH 4-5. The organic phase was washed with water, dried (NaSO4) and the solvent removed. (Yield approx. 60%)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Gruenenthal GmbH; US2009/69320; (2009); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem