Adding a certain compound to certain chemical reactions, such as: 496-12-8, name is Isoindoline, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 496-12-8, name: Isoindoline
Adding a certain compound to certain chemical reactions, such as: 496-12-8, name is Isoindoline, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 496-12-8, name: Isoindoline
Example 137:; EPO 137To a dichloromethane solution (8 ml.) of phosgene (769 uL, 20% in toluene, 1.45 mmol) at -70C was added triethylamine (234 mg, 2.32 mmol) and isoindoline (138 mg, 1.16 mmol). The mixture was slowly warmed to room temperature and stirred for 1 hour. To the reaction mixture were added 103d (245 mg, 0.980 mmol), triethylamine (147 mg, 1.45 mmol) and 4-(dimethylamino)pyridine (18 mg, 0.15 mmol). The mixture was stirred at room temperature for 72h. It was then diluted with ethyl acetate (30 ml_) and washed with cold 1 M HCI (20 ml_), cold 1 M sodium bicarbonate (20 mL) and brine (20 mL), dried with Na2SO4 and concentrated. After column chromatography (20-40% ethyl acetate in hexane), the title compound was obtained in 57% yield. 1H NMR (CDCI3): delta 7.44 (1H, dd, J=8.6, 5.3Hz), 7.4-7.2 (4H, m), 7.03 (1 H, dd, J=9.8, 2.2Hz), 6.86 (1 H, m), 4.98 (1 H, m), 4.71 (4H, m), 4.25 (2H, m), 3.37 (2H, m), 1.28 (3H, t, J=7Hz). LCMS (APCI): 396.1 (M+H+).
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Reference:
Patent; PFIZER, INC.; WO2006/40646; (2006); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem