Related Products of 39603-24-2, These common heterocyclic compound, 39603-24-2, name is 5,7-Dimethylindoline-2,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Will be perchloric acid (70%, 1 mmol, 142 mg) was added 5-methoxyisatin (1 mmol, 177 mg), 2-amino-5-chloro-pyridine (1.35 mmol, 174 mg) And tert-butylisocyanide (1.35 mmol, 112 mg) in n-butanol (4 mL) The reaction was stirred at reflux for 8 hours. When the reaction solution was cooled to room temperature, Filtration and washing the filter cake with a small amount of ethanol gave the desired product in 39% yield.
The synthetic route of 39603-24-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangdong South China New Drug Initiative Center; Lin Shuo; Che Chao; Li Song; Yang Bo; Xin Shengchang; (18 pag.)CN105017253; (2017); B;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem