Electric Literature of 3783-77-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3783-77-5, name is 2-(3-Oxobutyl)isoindoline-1,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
(1) Synthesis of N-[3-(N-methoxyimino)butyl]-phthalimide 1.08 g (5.00 mmol) of N-(3-oxobutyl)phthalimide was dissolved in 10 ml of methanol and to the solution was added 0.835 g (10.0 mmol) of O-methylhydroxylamine hydrochloride. To this suspension was added 2 ml of 5N aqueous sodium hydroxide solution, followed by being stirred at room temperature for 16 hours. The reaction mixture was poured into 100 ml of saturated aqueous sodium hydrogencarbonate solution and extracted with chloroform (30 ml*3), and the combined organic layer was dried over magnesium sulfate. Chloroform was distilled off and the residual solids were washed with hexane to give 1.23 g (yield 100%) of the titled compound as white crystals. Melting point 55-64 C., 1 H-NMR spectrum (DMSO-d6, TMS as internal standard); delta=1.86(s, 3H*0.66), 1.91(s, 3H*0.34), 2.5(t, J=6 Hz, 2H*0.66), 2.66(t, J=6 Hz, 2H*0.34), 3.48(s, 3H*0.34), 3.65(s, 3H*0.66), 3.84(t, J=6 Hz, 2H*0.66), 3.87(t, J=6 Hz, 2H*0.034), 7.85(s, 4H)ppm,
The synthetic route of 2-(3-Oxobutyl)isoindoline-1,3-dione has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Mitsubishi Gas Chemical Co., Inc.; US5211738; (1993); A;,
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