7477-63-6, name is 7-Chloroisatin, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C8H4ClNO2
General procedure: To a mixture of isatin or isatin derivatives (1 mmol) in DMF (1.5 mL) was added dried K2CO3 (165.5 mg, 1.2 mmol). The resulting mixture was stirred at 70oC for 1 hour, then 83 mg of KI (0.5 mmol) was added followed by slow addition of a solution of 3,4,5-trimethoxybenzyl clorid (216.7 mg, 1 mmol) in DMF (1 mL). The reaction mixture was stirred for a further 3 hours at 80oC, then cooled to room temperature. Cold water (20 mL) was slowly added to the cooled reaction mixture and pH was adjusted to ~ 6 by a solution of HCl 5percent to generate yellowish to brown precipitates, which were filtered, washed by cold water until neutrality. The precipitates were recrystallized by EtOH/H2O and dried at 60oC under vacuum.
The synthetic route of 7477-63-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Huan, Le Cong; Pham-The, Hai; Le-Thi-Thu, Huong; Thao, Tran Phuong; Que, Do Nguyet; Trang, Nguyen-Thu; Dung, Phan Thi Phuong; Pyo, Minji; Han, Sang-Bae; Thuan, Nguyen Thi; Nam, Nguyen-Hai; Letters in drug design and discovery; vol. 15; 4; (2018); p. 375 – 387;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem