Adding a certain compound to certain chemical reactions, such as: 496-12-8, name is Isoindoline, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 496-12-8, 496-12-8
(1) Pyridine (6.56 mL, 81.1 mmol) and dimethylaminopyridine (248 mg, 2.03 mmol) were added to a solution of isoindoline (8.08 g, 40.6 mmol) in chloroform (120 mL) at room temperature and the mixture was cooled in ice. Trifluoroacetic acid anhydride (6.77 mL, 48.7 mmol) was added dropwise thereto and the reaction mixture was warmed to room temperature and stirred for 4 hr. The reaction mixture was concentrated under reduced pressure and the residue was diluted with ethyl acetate. The mixture was washed with 1 mol/L hydrochloric acid, saturated aqueous sodium hydrogen carbonate solution and brine. The organic layer was dried over anhydrous magnesium sulfate and then the desiccant was filtered off, followed by concentration under reduced pressure. The resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate = 9:1) to afford 1-(1,3-dihydro-2H-isoindol-2-yl)-2,2,2-trifluoroethanone as a brownish red powder (8.66 g).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Isoindoline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Taisho Pharmaceutical Co., Ltd.; BUSUJIMA, Tsuyoshi; OI, Takahiro; TANAKA, Hiroaki; SHIRASAKI, Yoshihisa; IWAKIRI, Kanako; SATO, Nagaaki; TOKITA, Shigeru; EP2687507; (2014); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem