Synthetic Route of 13861-75-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13861-75-1, name is Spiro[cyclopropane-1,3′-indolin]-2′-one belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
The spiro [cyclopropane-1,3′-indol] -2′-one 63a (3g, 18.8mmol) was dissolved in 3mL of acetonitrile at room temperature was added 2-bromo-1,1-dimethoxyethane ( 3.34g, 19.7mmol), potassium carbonate (12.25g, 37.6mmol), potassium iodide (10mg), the reaction was stirred for 16 hours at room temperature. The reaction solution was concentrated under reduced pressure, the reaction solution was added 100mL of water, extracted with ethyl acetate (100mL × 2), and the combined organic phase was washed with water (100mL × 3), washed with saturated sodium chloride solution (100mL × 2), dried over anhydrous dried over sodium sulfate, filtered, and the filtrate concentrated under reduced pressure. By column chromatography (PE: EtOAc = 4: 1) to give purified 1 ‘- (2,2-dimethoxy-ethyl) spiro [cyclopropane-1,3′-indol] -2′-one 63b (2g, yellow solid), yield: 43.0%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Spiro[cyclopropane-1,3′-indolin]-2’-one, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Nanjing Mingde New Drug Research And Development Co. Ltd; HE, HAI-YING; SHI, WEI-HUA; JIANG, ZHI-GAN; HAN, LI-XIA; SUN, JI-KUI; LI, JIAN; CHEN, SHU-HUI; (175 pag.)TW2016/5834; (2016); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem