Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2436-29-5, name is 3-(1,3-Dioxoisoindolin-2-yl)propanal, A new synthetic method of this compound is introduced below., Product Details of 2436-29-5
Synthesis of Compound 42; A solution of 0.200 g (0.26 mmol) of 41,0. 262 g (1.29 mmol) of 3- (N-phthalimidyl)- propionaldehyde, and 0.110 g (0.52 mmol) of NaB (OAc) 3H in 1.5 mL of DMF was stirred at 25 C for 4 h. The reaction mixture was diluted with H20, extracted with CH2C12 (50 mL x 3), combined organic layers were washed with brine, dried over MgS04, concentrated, purified through silica gel column chromatography to give 0.200 g of product. MS (ESI) nVe 961 (M+H) Synthesis of triazole 460 A solution of 0.200 g (0.20 mmol) of alkyne 42,0. 080 g (0.41 mmol) of azide 14w, and 0.040 g (0.20 mmol) of Cul in 15 mL of THF was degassed, then put under argon. To it was added 0.2 mL of Hunig’s base. The reaction was stirred at 25 C for 6 h. Subsequently, to the mixture was added 40 rnL of 10% NH40H, stirred for 10 min, extracted with CH2C12 (50 ml x 3), the combined organic layers were washed with brine, dried, concentrated, purified by preparative TLC to give 0.098 g of compound 460. MS (ESI) iiz/e 1153 (M+H) +.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; RIB-X PHARMACEUTICALS, INC.; WO2005/85266; (2005); A2;,
Indoline – Wikipedia,
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