Adding a certain compound to certain chemical reactions, such as: 18711-13-2, name is 4,7-Dichloroindoline-2,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18711-13-2, Product Details of 18711-13-2
General procedure: To the stirred solution of beta-keto ester 2(aei) (1.0 mmol) and DABCO (30 mol %) in 5 mL THF was added isatin 1(aeh) (1 mmol).The mixture was then stirred at room temperature for stipulated time (5-8 h). After completion of reaction as indicated by TLC, thesolvent was removed at reduced pressure on a BUCHI rotary evaporator. The residue was then purified by column chromatography on silica gel (hexane/ethyl acetate4:1 to 1:1) to afford thedesired product 3(a-w).
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Reference:
Article; Thakur, Pramod Bhagwan; Sirisha, Katukuri; Sarma, Akella Venkata Subrahmanya; Nanubolu, Jagadeesh Babu; Meshram, Harshadas Mitaram; Tetrahedron; vol. 69; 31; (2013); p. 6415 – 6423;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem