324-03-8, Adding some certain compound to certain chemical reactions, such as: 324-03-8, name is 6-Fluoroindoline-2,3-dione, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 324-03-8.
Example 125 3-Cyclopentyl-2-(6-fluoro-2-oxo-2,3-dihydro-indol-1-yl)-N-thiazol-2-yl-propionamide A stirred suspension of sodium hydride (60% dispersion in oil, 290 mg) in N,N-dimethylformamide at 0 C. was treated with a solution of 6-fluoro-1H-indole-2,3-dione (1.0 g) in N,N-dimethylformamide (total volume, 20 mL). The reaction mixture was stirred for 30 min at 0 C. and then 2-bromo-3-cyclopentyl-propionic acid methyl ester (prepared as in Example 1, 1.71 g) was added and it was stirred for 1 h at 0 C. It was then slowly allowed to warm to room temperature and stirred for another 3 h at room temperature. After this time, the reaction mixture was diluted with water and extracted with methylene chloride (3*10 mL). The organic layers were combined and dried over sodium sulfate, filtered and the filterate concentrated in vacuo. The crude material was purified by column chromatography (silica gel, 5% ethyl acetate/hexanes) to afford 3-cyclopentyl-2-(6-fluoro-2,3-dioxo-2,3-dihydro-indol-1-yl)-propionic acid methyl ester (1.0 g, 52%).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 324-03-8.
Reference:
Patent; Kester, Robert Francis; US2012/142705; (2012); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem