In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 99365-40-9, name is 6-Bromoindolin-2-one belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. 99365-40-9
To a stirred mixture of 6-bromoindolin-2-one A.35 (5.0 g, 23.6 mmol) and NaHCO3 (10 eq., 21.0 g) in THF (130 mL) was added (Boc)2O (2.5 eq., 14.0 g) at room temperature under N2. The resulting mixture was heated at reflux for 3 h. After cooling, the mixture was vacuum filtered through a layer of celite and the filter cake was thoroughly washed with THF. The filtrate was concentrated in vacuo and the residue was subjected to combi-flash column chromatography (ethyl acetate/hexanes) to give tert-butyl 6-bromo-2-oxo-2,3-dihydro-lH- indole-1-carboxylate A.36 (6.0 g, 81% yield) as an off-white solid. 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 8.04 (1 H, d, J=I.6 Hz), 7.29 (1 H, dd, J=8.0, 1.8 Hz), 7.1 1 (1 H, d, J=7.8 Hz), 3.60 (2 H, s), 1.65 (9 H, s). LCMS-ESI (POS), M/Z, M+Na+: Found 334.0 and 336.0.
The synthetic route of 99365-40-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AMGEN INC.; WO2009/158011; (2009); A1;,
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