Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 552330-86-6, name is 5-Bromoisoindolin-1-one, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 5-Bromoisoindolin-1-one
A mixture of 5-bromoisoindolin-1-one (2-73, 200 mg, 0.95 mmol), 4,4,4?,4?,5,5,5?,5?-octamethyl-2,2?-bi(1,3,2-dioxaborolane) (2-57, 241 mg, 0.95 mmol), KOAc (186 mg, 1.9 mmol), and Pd(dppf)C12 (69 mg, 0.095 mmol) in dioxane (5 ml) was stirred for 16 h at 60 C. Upon reaction completion, the resulting mixture was washed with H20 and extracted with ethyl acetate (50 mL x 3). The combined organic phases were concentrated under reduced pressure and the resulting residue was purified via silica gel chromatography (Pet Ether/ ethyl acetate = 10/1) to obtain intermediate 2-74 (white solid, 300 mg, 88% yield). LCMS (m/z): 260 [M + Hj.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 552330-86-6.
Reference:
Patent; DANA-FARBER CANCER INSTITUTE, INC.; FONDAZIONE CENTRO SAN RAFFAELE; GRAY, Nathanael S.; BUHRLAGE, Sara; ANDERSON, Kenneth; COTTINI, Francesca; TONON, Giovanni; (288 pag.)WO2016/161145; (2016); A1;,
Indoline – Wikipedia,
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