Reference of 1168150-46-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1168150-46-6, name is (E)-Methyl 3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
N-methyl-2-(4-methylpiperazin-1-yl)-N-(5-aminopyridin-2-yl)acetamide (205mg, 0.78mmol) and methyl (E)-3-(methoxy(phenyl)methylene)-2-oxoindole-6-carboxylate (200mg, 0.65mmol) placed in 15mL of methanol was heated to 70 C, 13h of holding, and then cooled to room temperature, concentrate.The residue was purified by silica gel column (ethyl acetate / petroleum ether = 1/5 to 4/1) to give a yellow oil was isolated, after recrystallization (ethyl acetate / petroleum ether = 1/8) to give a bright yellow solid, methyl (Z)-(((6-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)pyridin-3-yl)amino(phenyl)methylene))-2-oxoindole-6-carboxylate (120mg, 34%).
The synthetic route of (E)-Methyl 3-(methoxy(phenyl)methylene)-2-oxoindoline-6-carboxylate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shandong Hengli medical science and Technology Co Ltd; Luo, haoxian; Wang, aichen; (42 pag.)CN103848814; (2016); B;,
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