Adding a certain compound to certain chemical reactions, such as: 7477-63-6, name is 7-Chloroisatin, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7477-63-6, Computed Properties of C8H4ClNO2
5mmol of o-phenylenediamine in turn,5mmol 7-chlorodione indole,6mmol iodoethane,1mmol p-toluenesulfonic acid,1mmol selective fluorine reagent,20ml of toluene was added to the round bottom flask,Stir at reflux at 70-90 C for 24 hours. After the reaction is complete, add 30 ml of brine to quench the reaction. The reaction mixture is extracted with 90 ml of ethyl acetate three times to extract the reaction product. An analytically pure 7-chloro-6-ethyl-6H-indole [2,3-b] quinoxaline was obtained. Red solid, 81% yield
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 7-Chloroisatin, and friends who are interested can also refer to it.
Reference:
Patent; South China Normal University; Guangzhou Huarui Optoelectric Materials Co., Ltd.; Song Xinlong; Zhou Guofu; Pan Junyou; (10 pag.)CN110283177; (2019); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem