Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 88150-75-8, name is Ethyl 4-(2-(1,3-dioxoisoindolin-2-yl)ethoxy)-3-oxobutanoate, A new synthetic method of this compound is introduced below., SDS of cas: 88150-75-8
Example 8a synthetic process of amlodipine besylate,The difference from Embodiment 1 is thatStep three is: in the reaction tank,Into a toluene solution of 4-[(2-phthalimido)ethoxy]acetic acid ethyl acetate,Distilled under reduced pressure at 70 C,Fill the water separator and continue to reflux under reduced pressure.Until the water content in the reflux liquid is ?0.2%, the temperature is lowered to 35 C, 27 kg of 2-chlorobenzaldehyde is added, and the internal temperature is maintained at 35 C.Add 1.5 kg of hexahydropyridine and stir for 30 minutes.Under the condition of 65 C, -0.09 Mpa, the water was refluxed under reduced pressure for 12 hours or more, the temperature was lowered to 35 C, and 120 kg of water was added.Stir,Let stand for 30 minutes,Layered, the lower aqueous layer is recovered, and the upper layer is a toluene solution of 2-(2-chloroindol)-4-[(2-phthalimido)ethoxy]acetic acid ethyl acetate; The yield of amlodipine was 91.2%, and the purity was 99.5%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Shanghai Fenglin Biological Technology Co., Ltd.; Zheng Yulin; Chen Yushuang; Liu Lijuan; Gao Huanhuan; Yu Yaoying; (13 pag.)CN108456160; (2018); A;,
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