102359-00-2, name is 2-Oxoindoline-5-carboxylic Acid, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 102359-00-2
Prepared from 2-oxoindoline-5-carboxylic acid (500.0 mg, 2.87 mmol), conc. HCl (1.0 mL), AcOH (6.0 mL) and 3,5-dichloro-4-hydroxybenzaldehyde (536.7 mg, 2.87 mmol), 95 oC, 16 h. Yield = 640.0 mg, 65% (E/Z mixture). Major isomer: 1H NMR (DMSO-d6, 400 MHz) delta 10.9 (s, 1H), 8.2 (s, 1H), 7.88 (d, J = 1.7, 8.4 Hz), 7.80 (s, 2H), 7.57 (s, 1H), 6.97 (s, 8.0 Hz, 1H); MS (ES) m/z 384.0 [M+H]+ LCMS RT = 0.83 min (1 min method).
The synthetic route of 102359-00-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Dumas, Megan E.; Chen, Geng-Yuan; Kendrick, Nicole D.; Xu, George; Larsen, Scott D.; Jana, Somnath; Waterson, Alex G.; Bauer, Joshua A.; Hancock, William; Sulikowski, Gary A.; Ohi, Ryoma; Bioorganic and Medicinal Chemistry Letters; vol. 29; 2; (2019); p. 148 – 154;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem