603-62-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 603-62-3, name is 3-Nitrophthalimide belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Step 1 : To a solution of potassium hydroxide (16.1 g, 286 mmol) in water (500 mL), was added 3-nitrophthalimide (25.0 g, 130 mmol) in portion at 0 C. The suspension was stirred at 0 C for 3 hours, and then heated to 30 C for 3 hours. To the solution, was added HCI (100 mL, 6N). The resulting suspension was cooled to 0 C for 1 hour. The suspension was filtered and washed with cold water (2 x 10 mL) to give 3-nitro-phthalamic acid as a white solid (24.6 g, 90% yield): 1H NMR (DMSOd5) delta 7.69 (brs, IH, NHH), 7.74 (t, J= 8 Hz, IH, Ar), 7.92 (dd, J = 1, 8 Hz, IH, Ar), 8.13 (dd, /= 1, 8 Hz, IH, Ar), 8.15 (brs, IH, NHH), 13.59 (s, 1eta, OH); 13C NMR (DMSO-d6) delta 125.33, 129.15, 130.25, 132.54, 136.72, 147.03, 165.90, 167.31.
The synthetic route of 3-Nitrophthalimide has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CELGENE CORPORATION; WO2008/39489; (2008); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem