In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2058-72-2, name is 5-Bromo-1-methylindoline-2,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Safety of 5-Bromo-1-methylindoline-2,3-dione
General procedure: A mixture of an N-substituted isatin (1.0 mmol), benzoyl cyanid (0.145 g, 1.1 mmol), and MS 4A (200 mg) in dry acetonitrile (2 mL) was stirred at room temperature for the indicated time (Table 2). The progress of the reaction was monitored by TLC. After completion of the reaction, the MS 4A was recovered by simple filtration, thoroughly washed with dry acetonitrile. Then the filtrate was evaporated to dryness in a rotary evaporator under reduced pressure and the residue was crystallized from a mixture of CH2Cl2 and petroleum ether, which yielded the pure products.
The synthetic route of 2058-72-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Esmaeili, Abbas Ali; Ghalandarabad, Saeid Amini; Zangouei, Mahdieh; Tetrahedron Letters; vol. 53; 42; (2012); p. 5605 – 5607;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem