Adding a certain compound to certain chemical reactions, such as: 324-03-8, name is 6-Fluoroindoline-2,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 324-03-8, 324-03-8
General procedure: Compound 2h was prepared from 6-fluoro-1H-indole-2,3-dione 1f and dl-leucine in a similar manner to that described for the synthesis of compound 2a and obtained in 64% yield as a yellow solid. 1H NMR (400 MHz, DMSO-d6) delta 0.86-0.91 (m, 6H), 1.31-1.45 (m, 2H), 1.61-1.69 (m, 1H), 1.79-1.89 (m, 1H), 2.16-2.23 (m, 1H), 2.93-2.96 (m, 1H), 3.12 (s, 3H), 3.28-3.32 (m, 1H), 3.42-3.53 (m, 1H), 6.55-6.61 (m, 1H), 6.66-6.74 (m, 1H), 7.01-7.09 (m, 1H), 10.45 (s, 1H). MS m/z 321 (M+H)+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-Fluoroindoline-2,3-dione, other downstream synthetic routes, hurry up and to see.
Reference:
Article in Press; Ito, Masahiro; Iwatani, Misa; Yamamoto, Takeshi; Tanaka, Toshio; Kawamoto, Tomohiro; Morishita, Daisuke; Nakanishi, Atsushi; Maezaki, Hironobu; Bioorganic and Medicinal Chemistry; (2017);,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem