Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3335-98-6, name is 1-Phenyloxindole, This compound has unique chemical properties. The synthetic route is as follows., category: indolines-derivatives
General procedure: All reactions were conducted in 10 mL glass vials fitted with crimpcap septum caps. The reaction vial, equipped with a magnetic stir bar, was charged under an N2 atmosphere with the oxindole (2.25 mmol),Pd2(dba)3 (51 mg, 0.056 mmol, 2.5 mol%), i-Pr-BI-DIME (7) (41 mg,0.112 mmol, 5 mol%), K2CO3 (932 mg, 6.75 mmol) and the aryl bromide(1.1 equiv), then sealed with a crimp-cap septum. Dioxane (5.0 mL, degassed) was added via syringe and the reaction was stirred in an oil bath at 100 C for 24 h. The reaction mixture was then cooled to room temperature and filtered through a Celite pad using EtOAc (15mL) as eluent. The filtered solution was washed with H2O (5 mL),dried over anhydrous Na2SO4 and then concentrated under reduced pressure. The crude residue was purified using a 12 g silica column(30% EtOAc/hexanes) to afford the desired oxindole product.
According to the analysis of related databases, 3335-98-6, the application of this compound in the production field has become more and more popular.
Reference:
Article; Mangunuru, Hari P. R.; Malapit, Christian A.; Haddad, Nizar; Reeves, Jonathan T.; Qu, Bo; Rodriguez, Sonia; Lee, Heewon; Yee, Nathan K.; Song, Jinhua J.; Busacca, Carl A.; Senanayake, Chris H.; Synthesis; vol. 50; 22; (2018); p. 4435 – 4443;,
Indoline – Wikipedia,
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