These common heterocyclic compound, 1029691-06-2, name is 2-(3-Oxocyclopentyl)isoindoline-1,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 1029691-06-2
[0604] To a mixture of DIPEA (5.32 g, 41.17 mmol) and 151 (5.9 g, 25.73 mmol) in DCM (100 mL) was dropwise added Tf2O (8.7 g, 30.9 mmol) at 0 oC for 30 min. The reaction was stirred at 0 oC for 16 hrs. After diluted with DCM, the mixture was washed with aq. NH4Cl solution and aq. NaHCO3 solution successively. The organic phase was dried over anhydrous Na2SO4, filtered and concentrated to give crude product, which was purified by column chromatography on silica gel (eluted with petroleum ether: ethyl acetate =4: 1) to give the title compound (6.3 g, 67.7% yield) as off-white solid.
The synthetic route of 2-(3-Oxocyclopentyl)isoindoline-1,3-dione has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WANG, Qiuping; GADHACHANDA, Venkat, Rao; WANG, Xiangzhu; DESHPANDE, Milind; PAIS, Godwin; CHEN, Dawei; WILES, Jason, Allan; HASHIMOTO, Akihiro; PHADKE, Avinash, S.; AGARWAL, Atul; (296 pag.)WO2017/35357; (2017); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem