Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 59-48-3, name is Indolin-2-one, This compound has unique chemical properties. The synthetic route is as follows., name: Indolin-2-one
1-methylindolin-2-one (S6). 60% sodium hydride (800 mg, 20 mmol) was added to a solution ofoxindole (2.66 g, 20 mmol) in toluene (60 mL) and stirred at 100 C for 1 hour. Dimethyl sulfate(1.90 mL, 20 mmol) was added and allowed to stir for an additional 2 hours. The reaction wasquenched with water, extracted with ethyl acetate, and concentrated. The crude product waspurified by column chromatography eluting with 20% ethyl acetate/hexanes to yield S6 (1.17 g,40%) as an off white solid.Rf: 0.13 (20% ethyl acetate/hexanes).1H NMR (400 MHz, CDCl3): delta 7.32 – 7.26 (m, 1H), 7.26 – 7.23 (m, 1H), 7.04 (td, J = 7.6, 0.9Hz, 1H), 6.82 (d, J = 7.8 Hz, 1H), 3.52 (s, 2H), 3.21 (s, 3H)13C NMR (101 MHz, CDCl3): delta = 175.3, 145.4, 128.0, 124.7, 124.5, 122.5, 108.2, 35.9, 26.3
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 59-48-3.
Reference:
Article; Fosu, Stacy C.; Hambira, Chido M.; Chen, Andrew D.; Fuchs, James R.; Nagib, David A.; Chem; vol. 5; 2; (2019); p. 417 – 428;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem