Related Products of 6326-79-0, A common heterocyclic compound, 6326-79-0, name is 6-Bromoisatin, molecular formula is C8H4BrNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The solution of 6-bromoisatin (10 g, 22 mmol) in IN aqueous NaOH solution (48 mNo.) was stirred at 50 0C for 1 h. The mixture was cooled to 0 0C Sodium nitrite (3 g, 22 mmol) solution in water (11 m-6) was added drop wise for 15 min at 0 0C The mixture was added to the solution of water (90 mNo.) and sulfuric acid (4.6 mNo.) at 0 0C for 15 min. The mixture was added to the solution of cone, hydrochloric acid (40 m-6) and SnCl2.2H 2O (24 g, 53 mmol). After 1 h, the mixture was filtered and washed with water. The solid was dried through air flow to give the titled compound (8.98 g).[185] [186] 1H NMR (300 MHz, DMSOd6) delta 13.76 (bs, IH), 7.87 (s, IH), 7.55 (d, J = 8 Hz, IH), 7.27 (d, J = 8 Hz, IH), 2.44 (s, 3H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY; SIM, Tae Bo; SON, Jung Beom; KIM, Hwan; PARK, Dong Sik; CHOI, Hwan Geun; HAM, Young Jin; HAH, Jung Mi; YOO, Kyung Ho; OH, Chang Hyun; LEE, So Ha; HA, Jae Du; CHO, Sung Yun; KWON, Byoung-Mog; HAN, Dong Cho; WO2010/64875; (2010); A2;,
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