These common heterocyclic compound, 20780-72-7, name is 4-Bromoisatin, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C8H4BrNO2
4-bromoisatin 1.0g (4.4mmol), methyl acrylate 0.46g (5.3mmol), PdCl2(PPh3)2 0.15g (0.22mmol), K3PO4 1.6g (6.2mmol). Place into microwave reaction flask. Add 5 ml DMF. Place under argon protection. In the microwave reactor 145 °C reaction 30min. TLC detection after the reaction is complete, the reaction solution with 100 ml saturated salt water washing 3 times, dichloromethane is used for extraction, the combined organic phase, anhydrous sodium sulfate drying, developing agent for petroleum ether: ethyl acetate=5:1 – 1: 1,200 – 300 mesh silica gel column chromatography purification, be 4 – acrylic acid methyl ester indole dione 0.65g, yield 64percent.
The synthetic route of 4-Bromoisatin has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Tianjin Kunjian Bio-pharmaceutical Co., Ltd.; Yu Peng; Han Kailin; Mao Huihua; Qiu Dongxu; (8 pag.)CN104387312; (2017); B;,
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Indoline | C8H9N – PubChem