52351-75-4, The chemical industry reduces the impact on the environment during synthesis 52351-75-4, name is 6-Methoxyindoline-2,3-dione, I believe this compound will play a more active role in future production and life.
5.0 g (1 equivalent) of 6-methoxyisatin was dissolved in 25 ml of ethanol.Add 4 ml (1.1 equivalents) of acetophenone and 5.2 g (3 equivalents) of potassium hydroxide solid, heat at 80 C under reflux, and stir for 48 hours.The heating and stirring were stopped, the ethanol was concentrated to dryness, and extracted with ethyl acetate and water three times. The organic phase was combined, and the organic phase was concentrated by spin-drying, and then neutralized by adding 2N diluted hydrochloric acid in an ice bath to precipitate a solid. After the test paper was detected to be weakly acidic, the acid was stopped to be added dropwise, and the mixture was allowed to stand for filtration, and the filter cake was washed with water to obtain 6.20 g of a pale red solid. The yield was 74%.
The chemical industry reduces the impact on the environment during synthesis 6-Methoxyindoline-2,3-dione. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Sun Yat-sen University; Wang Yuanxiang; Zhang Xiaolei; Huang Qiuyao; Zhong Yan; Hu Wenhao; (26 pag.)CN110105279; (2019); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem