3416-57-7, name is 2-(2-Oxopropyl)isoindoline-1,3-dione, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 3416-57-7
To a mixture of N-acetonylphthalamide 3 (8.8 g, 43.3 mmol) and pyrrole (40 mL) was added TFA (3.2 mL, 43.3 mmol) in one portion. The reaction solution was stirred for 10 h at room temperature. The reaction was quenched by adding triethylamine (5 mL). The residual pyrrole was then removed by evaporation in vacuo. To the resulting brownish sticky oil, CH2Cl2 (150 mL) and 10% aqueous NaOH (100 mL) were added, before the organic layer was separated off and washed three times with 120 mL of water. The organic layer was dried over anhydrous MgSO4 and the solvent was removed invacuo to give a brownish sticky oil. The crude product was purifiedby column chromatography over silica gel (1:1 ethyl acetate: hexanesv/v) to give 6.17 g (44.7% yield) of 4 as a pale yellowish solid: 1H NMR (600 MHz, DMSO-d6) delta 10.39 (s, 2H), 7.80 (s, 4H), 6.60-6.59 (q, 2H, J = 2.4 Hz), 5.85-5.84 (q, 2H, J = 2.4 Hz), 5.79-5.78 (m, 2H), 4.07 (s, 2H), 1.57 (s, 3H); 13C NMR (150 MHz, DMSO-d6) delta 167.6, 135.0, 134.1, 131.5, 122.8, 117.1, 106.3, 104.4, 46.8, 40.5, 24.4. HRMS(ESI): m/z calcd for C19H17N3O2 [M – H]-: 318.1243; found 318.1249.
Statistics shows that 3416-57-7 is playing an increasingly important role. we look forward to future research findings about 2-(2-Oxopropyl)isoindoline-1,3-dione.
Reference:
Article; He, Ying-Chun; Ren, Zhen-Xing; Zhao, Xue-Feng; Zhang, Yong-Bin; Wang, Jun-Hong; Chao, Jian-Bin; Wang, Meng-Liang; Tetrahedron; vol. 75; 36; (2019);,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem