These common heterocyclic compound, 19155-24-9, name is 3,3-Dimethylindolin-2-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 3,3-Dimethylindolin-2-one
(d) 3,3-Dimethyl-5-nitroindolin-2-one A solution of 22 ml. fuming nitric acid in 200 ml. 80percent sulphuric acid is added dropwise, with cooling, to a solution of 100 g. (0.62 mol) 3,3-dimethylindolin-2-one in 500 ml. 80percent sulphuric acid. The reaction mixutre is then stirred for about 30 minutes, poured on to ice, filtered with suction, washed with water and dried. Yield: 100 g. (78percent of theory); m.p. 192°-196° C. (ethyl acetate/heptane).
The synthetic route of 3,3-Dimethylindolin-2-one has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Boehringer Mannheim GmbH; US4666923; (1987); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem