Reference of 32692-19-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 32692-19-6 as follows.
To a solution of 5-nitroindoline (5.718 g) in DMF (60 mL) at 0C was sequentially added Nai l (1.348 g, 60% dispersion in mineral oil) and l-bromo-2-methoxyethane (5.368 g). The mixture was stirred at 0C for 2 h, and then was allowed to warm up to room temperature and stirred for another 3 h. At this point, TLC indicated the reaction to be complete. The reaction mixture was poured onto ice-water. The precipitate was collected, and re-dissolved in ethyl acetate. The organic layer was washed with water, brine and concentrated under reduced pressure to afford the desired product 1 (7.292 g, 94%, M+H+= 223.3) as a yellow solid.
According to the analysis of related databases, 32692-19-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ACEA BIOSCIENCES INC.; XU, Xiao; WANG, Xiaobo; MAO, Long; ZHAO, Li; XI, Biao; WO2015/6754; (2015); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem