Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 552330-86-6, name is 5-Bromoisoindolin-1-one, A new synthetic method of this compound is introduced below., Recommanded Product: 552330-86-6
5-Bromoisoindolin-1-one (10 g, 47.16 mmol) and sodium ethanethiolate (9.92 g, 117.90mmol) were mixed together in DMF (100 mL) and the reaction heated to 100 C for 20mm. The reaction was cooled to rt, poured into water (100 mL) and the product extractedwith EtOAc (3 x 200 mL). The combined organic extracts were washed with brine (4 x 50mL). LCMS indicated product in the aqueous washings, and consequently they werecombined and extracted with EtOAc (4 x 50 mL). The organic extracts were combined, dried using a phase separator cartridge and concentrated in vacuo. The solid obtained was dried under high vacuum overnight. 5-(Ethylthio)isoindolin-1-one (8.68 g, 95%) was obtained as a yellow solid. The material was used in the next step without furtherpurification.LC/MS: m/zrr 194 [M+H]. ?H NMR (500 MHz, DMSO-d6) i5 1.27 (t, 3H), 3.06 (q, 2H), 4.33 (s, 2H), 7.36 (dd, 1H), 7.47 – 7.48 (m, 1H), 7.57 (d, 1H), 8.45 (s, 1H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ASTRAZENECA AB; LEVER, Sarah; NARJES, Frank; OLSSON, Roine, Ingemar; VON BERG, Stefan; (124 pag.)WO2018/229155; (2018); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem