Adding a certain compound to certain chemical reactions, such as: 89-40-7, name is 5-Nitroisoindoline-1,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 89-40-7, COA of Formula: C8H4N2O4
4-Nitrophthalimide (LOOGR) was taken into a hydrogenation kettle and dissolved using 700ML of dimethylformamide. 5% PALLADIUM/CARBON (LOGR, 50% wet) was added to the solution and hydrogenated initially at 20-30C under 20-40psi. After the exothermic nature of the reaction was over, hydrogen pressure was increased to 40-60psi and the temperature to 40-50C. After the hydrogenation was over the reaction mixture was filtered while hot and the catalyst removed by filtration. Dimethylformamide was removed from the filtrate under reduced pressure at 60-80C. Water (500ML) was added to the residue and the mixture stirred for 30MIN. The product was isolated by filtration and dried at 60-70C to get 80gr (95%) of yellow crystalline solid of 4- aminophthalimide. Melting point: 294-5C.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Nitroisoindoline-1,3-dione, and friends who are interested can also refer to it.
Reference:
Patent; NATCO PHARMA LIMITED; VENKAIAH CHOWDARY, Nannapaneni; WO2004/43919; (2004); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem