Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5394-18-3, name is 2-(4-Bromobutyl)isoindoline-1,3-dione, A new synthetic method of this compound is introduced below., Product Details of 5394-18-3
To a cooled solution of 1 /-/-imidazole (200 mg, 3.085 mmol, 1.05 eq) in DMF (7 ml_), NaH 60% in mineral oil (136 mg, 3.393 mmol, 1.1 eq.) was added portionwise and the mixture was stirred for 10 min. Afterwards, a solution of 2-(4-bromobutyl)-2,3-dihydro-1 7Aisoindole-1,3-dione (870 mg, 3.085 mmol, 1 eq.) in DMF (3 ml.) was added dropwise. The reaction was continued at 60C for further 16 h. The reaction was quenched with water and diluted in AcOEt. The layers were separated. Organic layer was dried, filtered off and concentrated in vacuo. The residue was purified by FCC (SiHP, DCM: MeOH 95:5) to afford the title compound (323 mg, 1.2 mmol, yield 40%) as a white solid. ESI-MS: 270 [M+H]+ 1H NMR (300 MHz, Chloroform-o) d 7.89 – 7.85 (m, 2H), 7.77 – 7.73 (m, 2H), 7.50 (t, J= 1.1Hz, 1H), 7.07 (t, J= 1.1Hz, 1H), 6.93 (t, J= 1.3 Hz, 1H), 4.02 (t, J= 7.0 Hz, 2H), 3.74 (t, J= 6.8 Hz, 2H), 1.91 – 1.79 (m, 2H), 1.78 – 1.64 (m, 2H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; RYVU THERAPEUTICS S.A.; DOBRZANSKA, Monika Patrycja; ZAWADZKA, Magdalena Izabela; RADZIMIERSKI, Adam; TOPOLNICKI, Grzegorz Witold; CWIERTNIA, Grzegorz Wojciech; MAHAJAN, Tushar Ravindra; FABRITIUS, Charles-Henry; CHMIELEWSKI, Stefan; GLUZA, Karolina Maria; ALVAREZ, Jose; ROGACKI, Maciej Krzysztof; MROCZKOWSKA, Magdalena; (215 pag.)WO2019/238786; (2019); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem