The chemical industry reduces the impact on the environment during synthesis 603-62-3, name is 3-Nitrophthalimide, I believe this compound will play a more active role in future production and life. 603-62-3
4-Nitroisoindoline (1): To a solution of 4-nitroisoindoline-l,3-dione (1.0 g, 5.2 mmol) in dry THF (20 mL) was added 1M borane solution in THF (21.0 mL, 20.8 mmol) at 0 C and then heated to 80-85 C for 12 h. The reaction mixture was treated with MeOH (2 mL) and 6N HC1 (5 mL) and refluxed for 1 h. The reaction mass was brought to room temperature and volatiles were removed under reduced pressure. The residue was dissolved in EtOAc (50 mL) and basified with saturated NaHC03 (10 mL). Organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to obtain 1 (500 mg, 59%) as white solid. 1H NMR (500 MHz, DMSO-d6): delta 4.15 (s, 2H), 4.45 (s, 2H), 7.49 (t, J = 8.0 Hz, 1H), 7.71 (d, J = 8.0 Hz, 2H), 8.02 (d, J = 7.5 Hz, 1H).
The chemical industry reduces the impact on the environment during synthesis 603-62-3. I believe this compound will play a more active role in future production and life.
Reference:
Patent; CELGENE AVILOMICS RESEARCH, INC.; ALEXANDER, Matthew David; MCDONALD, Joseph John; NI, Yike; NIU, Deqiang; PETTER, Russell C.; QIAO, Lixin; SINGH, Juswinder; WANG, Tao; ZHU, Zhendong; WO2014/149164; (2014); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem