59-48-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 59-48-3 as follows.
A solution of 2-indole ketone (5 g, 37.6 mmol ) in H2SO4 (50 mL) was stirred at 0 C for 30 min, then a solution of KNO3 (3.04 g, 30 mmol ) in H2SO4 (5 mL) was added slowly, and then the mixture was stirred for 15 min. The mixture was poured in ice water, and the product was precipitated from solution, collected by suction filtration, washed with methanol and dried to give 4.5 g as a pale yellow solid. 1H NMR (400 MHz, DMSO-d6) delta: 11.04 (s, 1H), 8.15 (dd, J = 8.6, 2.3 Hz, 1H), 8.09 (d, J = 2.2 Hz, 1H), 6.98 (d, J = 8.6 Hz, 1H), 3.64 (s, 2H); 13C NMR (100 MHz, DMSO-d6) delta: 177.0, 150.7, 142.2, 127.5, 125.3, 120.4, 109.4, 36.0.
According to the analysis of related databases, 59-48-3, the application of this compound in the production field has become more and more popular.
Reference:
Article; Han, Weina; Huang, Jian; Jiang, Jin; Ruhan, A.; Wang, Jinhui; Yao, Dahong; Bioorganic and medicinal chemistry letters; vol. 30; 17; (2020);,
Indoline – Wikipedia,
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