Adding a certain compound to certain chemical reactions, such as: 32372-82-0, name is Isoindoline hydrochloride, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 32372-82-0, 32372-82-0
General procedure: To a solution of 10 (371 mg, 1.00 mmol) in DMF (5 mL) was added EDC (195 mg, 1.02 mmol), and the resulting mixture was stirred at room temperature for 1 h. Then, to the reaction mixture stirred under ice-cooling was added 12n (192 mg, 1.04 mmol) and N,N-diisopropylethylamine (0.180 mL, 1.06 mmol), and the mixture was stirred at 0 C for 1 h. To the reaction mixture was added 1-(2-aminoethyl)pyrrolidine (0.140 mL, 1.12 mmol), HOBt (174 mg, 1.14 mmol), and EDC (220 mg, 1.15 mmol), and the resulting mixture was stirred at room temperature for 6 h. The reaction mixture was diluted with EtOAc, and the organic layer was washed with H2O, saturated aqueous NaHCO3, and brine, and dried over Na2SO4. The insoluble material was filtered off, and the solution was concentrated under reduced pressure. The residue oil was purified by NH silica gel column chromatography (hexane/EtOAc = 50:50 to 0:100) to afford 14n (497 mg, 83%) as a colorless solid.
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Reference:
Article; Nakao, Akira; Suzuki, Hiroko; Ueno, Hiroaki; Iwasaki, Hiroshi; Setsuta, Tomofumi; Kashima, Akiko; Sunada, Shinji; Bioorganic and Medicinal Chemistry; vol. 23; 15; (2015); p. 4952 – 4969;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem