Synthetic Route of 41663-84-7,Some common heterocyclic compound, 41663-84-7, name is 2-Methyl-5-nitroisoindoline-1,3-dione, molecular formula is C9H6N2O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In the homogeneous mixing of three reaction bottle, under the protection of nitrogen at room temperature by adding 300 mL of dimethylsulfoxide (moisture <500ppm). Then, 150 g of N-methyl-4-nitrophthalimide and 169 g of sodium phenolate were added, Heated to 120 C for 24 hours. Cooled to room temperature, The reaction solution was slowly added to 900 mL of ice water in China, Stirring for 30 minutes, filtering, filter cake with water 150mL * 3 washing, filter cake out to get the product 171g, the yield of 93%, HPLC purity of 98% These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Methyl-5-nitroisoindoline-1,3-dione, its application will become more common.