Synthetic Route of 552330-86-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 552330-86-6 name is 5-Bromoisoindolin-1-one, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
(6-(1-(and 2-)(4-methoxybenzyl)-2H-tetrazol-5-yl)-4?-methyl-5-sulfamoyl-[1,1?-biphenyl]-3-yl)boronic acid (40 mg, 0.083 mmol) and 6-bromoisoindolin-1-one (19.47 mg, 0.092 mmol) was suspended in ethanol (835 mul) and potassium phosphate tribasic (250 mul, 0.250 mmol). The reaction mixture was sparged with N2 for 5 min. 1,1?-bis(di-tert-butylphosphino)ferrocene palladium dichloride (5.44 mg, 8.35 mumol) was added and the reaction mixture microwaved at 110 C. for 90 min. The crude reaction mixture was diluted with EtOAc and water. The aqueous phase was extract with EtOAc (×2), then the combined extracts were washed with brine, dried over Na2SO4, filtered, and concentrated. The reaction mixture was purified by reverse phase HPLC on a C18 column and then eluted with 10% to 100% MeCN in water. The major UV active material was lyopholized to provide a white solid that was utilized directly in the deprotection. LC-MS: calculated for C30H26N6O4S 566.2; observed m/e: 467.5 (M+H)+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Bromoisoindolin-1-one, and friends who are interested can also refer to it.