Application of 25369-33-9, These common heterocyclic compound, 25369-33-9, name is 7-Chloroindolin-2-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of Scheme 9-1 compound 1 (1 equiv) in acetonitrile (10 vol) at 0 C was added NBS (1.1 equiv). The reaction mixture was stirred at room temperature for 3 h and then quenched with water. The resulting mixture was extracted with ethyl acetate. The organic layer was separated, dried over anhydrous Na2S04, filtered and then concentrated. The residue was purified by column chromatography on silica gel to afford Scheme 9-1 compound 2.
Statistics shows that 7-Chloroindolin-2-one is playing an increasingly important role. we look forward to future research findings about 25369-33-9.