Adding a certain compound to certain chemical reactions, such as: 2436-29-5, name is 3-(1,3-Dioxoisoindolin-2-yl)propanal, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2436-29-5, Computed Properties of C11H9NO3
150.0 mg (0.42 mmol) of (1 R)- 1- [1 -benzyl-4-(2,5-difluorophenyl)- I H-pyrrol-2-yl] -2,2-dimethyipropan-1-amine (intermediate C52) were initially charged in 2.0 ml of dichloromethane, and 29.2 mg (0.49mmol) of HOAc and 125.6 mg (0.59 mmol) of sodium triacetoxyborohydride were added and the mixture was stirred at RI for 5 mm. 98.9 mg (0.49 mmol) of 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2- yl)propanal were added. Ihe reaction mixture was stirred at RI overnight. Ihe reaction mixture was then diluted with ethyl acetate and the organic phase was washed twice with saturated sodium carbonate solution and once with saturated NaC1 solution. After drying over magnesium sulphate, the solvent wasevaporated under reduced pressure and the residue was purified using silica gel (mobile phase:dichloromethane/methanol 100:1). The solvents were evaporated under reduced pressure and the residue was dried under high vacuum. Ihis gave 188.6 mg (74%) of the compound 2-[3-({(1R)-1-[1-benzyl-4- (2,5-difluorophenyl)- 1 H-pyrrol-2-yl] -2,2-dimethylpropyl} amino)propyl] -1 H-isoindole- I ,3(2H)-dione.LC-MS (Method 1): R1 = 1.00 mm; MS (ESIpos): mz = 541 [M+H]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-(1,3-Dioxoisoindolin-2-yl)propanal, and friends who are interested can also refer to it.