Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 13861-75-1, name is Spiro[cyclopropane-1,3′-indolin]-2′-one, A new synthetic method of this compound is introduced below., SDS of cas: 13861-75-1
1-4 (6.0 g, 37.7 mmol) was dissolved in chloroform (480 mL), and PIFA (19.5 g, 45.2 mmol) and trifluoroacetic acid (43 g, 376.9 mmol, 28 mL) were added. The reaction mixture was stirred at 25 C for 12 hours. The reaction mixture was neutralized with a saturated sodium carbonate solution to pH = 7-8, extracted with dichloromethane/methanol (100 mL × 3), and the organic layer was washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was washed with petroleum ether/ethyl acetate (100 mL × 2), and filtered to give the target compound 1-5. 1H NMR (400MHz, CHLOROFORM-d) delta 6.68 – 6.70 (d, J = 8.0 Hz 1H), 6.55 – 6.58 (m, 2H), 6.26 – 6.27 (d, J = 2.0 Hz 1H), 1.59- 1.62 (m, 2H), 1.38 – 1.41 (m, 2H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.