Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 893620-44-5, name is 6-Bromo-5-fluoroindolin-2-one, A new synthetic method of this compound is introduced below., COA of Formula: C8H5BrFNO
d) 6-Bromo-5-fluoro-1,3,3-trimethylindolin-2-one To a suspension of NaH (5.04 g, 126 mmol) in tetrahydrofuran (105 ml) 6-bromo-5- fluoroindolin-2-one (7.24 g, 31.5 mmol) was added portionwise under an argon atmosphere. After gas evolution had ceased methyl iodide (17.9 g, 7.88 ml, 126 mmol) was added dropwise within 50 minutes by means of a syringe pump (exothermic reaction), keeping the temperature of the reaction mixture between 24 C and 26 C. The reaction mixture was kept at roomtemperature for 4 hours and then carefully quenched with aqueous ammonium chloride solution. The reaction mixture was diluted with tert-butyl methyl ether, water and saturated aqueous ammonium chloride solution. The aqueous phase was extracted with tert-butyl methyl ether, the combined organic phases were washed with saturated aqueous ammonium chloride and dried over sodium sulfate. The solvent was evaporated and the residue was triturated with heptane to give the title compound as light brown solid (7.87 g).MS ESI (m/z): 272.1, 274.1 [(M+H)i.H NMR (CDC13, 400 MHz): (ppm) = 7.02-6.97 (m, 2H), 3.19 (s, 3H), 1.36 (s, 6H).
The synthetic route of 893620-44-5 has been constantly updated, and we look forward to future research findings.