Adding a certain compound to certain chemical reactions, such as: 366453-21-6, name is 4-Hydroxy-2,3-dihydroisoindol-1-one, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 366453-21-6, HPLC of Formula: C8H7NO2
A solution of DEAD (250 muL, 1.59 mmol) in THF (1 mL) was added dropwise to a solution of 1 h (50.6 mg, 0.17 mmol), Ph3P (54.5 mg, 0.21 mmol) and phenol 2d (24.9 mg, 0.17 mmol) in THF (1.8 mL) at room temperature. After 16 h, the mixture was concentrated under reduced pressure and the residue was purified by flash chromatography (EtOAc/EtOH, 92/8) to give compound 101 (20 mg, 28% yield) as a white solid.
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