In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 19727-83-4, name is 6-Nitroindoline belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 6-Nitroindoline
5-Nitroindoline (12.18mmol, 2g) was stirred in acetic acid (50ml_) in an ice bath, tert- Butyl 4-oxopiperidine-1 -carboxylate (14.62mmol, 2.91 g) was added, followed by the portionwise addition of sodium triacetoxyhydroborate (18.27mmol, 3.87g). The reaction mixture was stirred for 1 hour at room temperature. The reaction mixture was concentrated at reduced pressure. The resulting residue was taken up in ethyl acetate and washed with saturated sodium bicarbonate solution. The organic phase was concentrated at reduced pressure to afford the title compound (5.2g).MS (ESI) m/z 348.1 [M+H]+
The synthetic route of 19727-83-4 has been constantly updated, and we look forward to future research findings.