These common heterocyclic compound, 6326-79-0, name is 6-Bromoisatin, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 6-Bromoisatin
General procedure: The targeted compounds have been synthesized as previouslydescribed (38). This approach consists in the couplingof a correctly substituted isatin and the 3-acetoxyindole inalkaline methanol to afford the indirubin skeleton. Then, the3¢-position reacts with hydroxylamine in refluxing pyridine leading to the corresponding indirubin-3¢-oxime. To a solutionof the corresponding indirubin in pyridine, hydroxylaminehydrochloride was added. The mixture was warmed inreflux for 1.5 h. After completion and cooling to 70C, waterwas added. The resulting precipitate was filtered, washedwith water and cyclohexane, and dried to afford the correspondingoxime as a red solid with 100%.796 was synthesized after acetylation of the oxime as waspreviously described (38) and was obtained with 100% yield.For synthesis of 6BIO-Pip, the corresponding indirubin-3¢-oxime was dissolved in anhydrous dimethylformamide(DMF). Then, 1,2-dibromoethane and a catalytic amount oftriethylamine were added and the mixture was stirred at 50Cfor 24 h. After completion, water was added and the precipitatefiltered, washed with water, and dried. The ether wasdissolved in anhydrous DMF. The corresponding amine wasthen added and the resulting mixture was warmed at 80Cunder a radiation of 150W for 20 min. After completion,water is added and the resulting precipitate is filtered, washedwith water, and dried. The corresponding derivatives areobtained as purple solid.
The synthetic route of 6-Bromoisatin has been constantly updated, and we look forward to future research findings.