Adding some certain compound to certain chemical reactions, such as: 71294-03-6, name is 7-Fluoroindolin-2-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 71294-03-6. 71294-03-6
7-Fluorooxindole (1.51 g, 10 mmol) and lithium chloride (1.06 g, 25 mmol) were suspended in 30 mL of THF and cooled to 0 C. n-Butyllithium (10 mL, 20 mmol) was added slowly and the mixture was stirred for 20 minutes. Iodomethane (1.24 mL, 20 mmol) was added and the mixture was stirred at 0 C. for 1 hour then warmed to 25 C. and stirred for 16 hours. The reaction was quenched with saturated aqueous NH4Cl and diluted with ethyl acetate. The organics were washed with water, saturated aqueous NaCl, dried over MgSO4, and concentrated. Flash chromatography (5% acetone/hexane) afforded the title compound 0.12 g (7%) as a white solid.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 7-Fluoroindolin-2-one.
Reference:
Patent; Wyeth; US2006/9509; (2006); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem